A breakout board is a device that "breaks out" the wires coming from a motion controller or parallel port into terminals to allow easy connection to your devices.
As such, it has nothing to do with the operating system.
What doesn't work with Windows 10 (or 64 bit OS's) is the parallel port driver in Mach3.
But, Mach3 itself works in Windows 10, provided you use an external motion controller like a Smoothstepper, or one of the 20-30 alternatives.

So, if you want to use Windows 10, you need a motion controller, but you can use just about any breakout board you want with that motion contoller.