Advice for cutting acrylic sheet

[magicniner]

...and a cheap cigar is still a smoke!

But I'd rather you than me ;-)

[Kitwn]

One fixing method I use for thin wood and acrylic is to firmly clamp the blank down as normal to a sacrificial base and start the cutting with a stand-alone drilling operation to create fixing holes between the parts to be cut. Where possible I also cut holes that are part of the pieces at this point. Fixing screws can then be used at many places within the sheet, not just clamps at the edges. The clamps can them be removed to allow cutting out to the edges of the piece if required.
Depending on what holes are part of the piece to be cut and what extra holes you can tolerate adding, this method can be used to avoid the need for holding tabs.

This works well but needs to be planned carefully and the fixing holes are best drawn on their own layer as part of the overall layout design.