A couple of beginner questions... Profile sizes and cutting area size.

[JAZZCNC]

If I knew then what I know now, I might well have configured my own machine to have X running left to right in front of me - the conventional XY layout - even though the machine would then be portrait rather than landscape. Main thing is to understand what you are doing!

It's always better to have it setup up in the direction you view the machine. It doesn't really matter whether X runs across gantry or down machines length but it should always run left to right as you view machine and in a positive direction like the cartesian coordinate system does. Y should always run away and towards you, again positive direction moving away from you. Otherwise, it gets confusing quickly.