Aluminium Profile Type Router - Initial questions

[JAZZCNC]

I have this for the cabinet layout - does it look OK or any issues?

You need to think about how the wires run and trunking. how you have it there would be awkward for running wires etc.
I would move the drives away from the Transformer and bring the DC PSU and MCB's etc down near the Transformer so all together in one area. If you have room even bring the VFD into the same area, this way all the high voltage stuff is together.

I would have the drives and controller close together to keep Signal wire runs short as possible. Separate the high power stuff from the Low voltage stuff by placing high and low in the case with Terminal blocks and Relays etc along with trunking between them, essentially dividing the case into 3 areas.
This doesn't matter if it's separated horizontally or vertically, for instance, I often run the drives along the sides of the case vertically as it's easier to wire them. On the opposite side, I will place VFD at the top and PSU, etc below. In the middle will be Terminals and Controller.

Also, I would think about having 2 fans in the case to create a positive pressure in the case to push hot air out.

Edit: Noticed that you have a Pilz relay shown, you don't actually need a safety relay. A normal Relay will work just as well and save you a lot of money.

Lastly, looking at your drawing the scale looks wrong on the parts shown so be very careful when planning out the box because it's SO EASY to run out of room. Often the case will look massive when empty but it quickly fills up. Also if you haven't got the box to measure from then allow a little extra because things like hinges or Earth clamps etc can rob precious space and easily screw up layout plans.
Also if not got a case and solely planning layout in Cad or on paper then I'd try to get exact dimensions of any components because again can soon run out of space and no matter what you do or how you twist things around it just won't fit.!