The CAD software is unrelated to Mach3; I use Mach3 to run the CNC.
However, that has nothing to do with whichever design software you choose to use.
To give you an idea, my CNC is in the warehouse running on Windows 7.
I create the design and generate the G-code at home on Windows 10 using Vectric Aspire.

Are you perhaps referring to the connection between Mach3 and the computer?