Some of the digital drivers have a stall-detect feature which changes an output on the driver if the motor stalls. You can connect this to the e-stop so that the machine stops moving to prevent any damage should only one of two motors stall. However I don't think this feature alone is that big an advantage since if you're stepper motors are stalling, even just occasionally, then there is something wrong with the system - either you are trying to get too high acceleration/speed from the motors or there's a mechanical fault. If there's something causing the motors to stall then one should find the problem, not compensate with a safety feature.

Once you have tuned the motors properly they will not miss steps or stall. Plenty of people, myself included, use two stepper motors on their X-axis with standard drivers and do not have problems.