Quick answer... yes. You'll need to get acquainted with your scam post and with mach macros. However it's all been done before in a variety of ways so a quick google will give you more info.
"Small" hole cutting in plasma is quite a topic in its own right so you'll probably want to read up on other things you can do to improve their quality. (A lot depends on your machine's rigidity and accel capabilities and of course just HOW good you need your small holes to be).

Ian