I can't see a problem but would need 2 blocks.
Regards the lead then depends on the work your doing and the micro stepping your using on the drives.
For Mainly wood use then 20mm lead will be ok and with average 800 micro-steps then you'll have theoretical resolution of approx 0.02mm which is plenty for wood.!! . . . . You'll also have massive OTT speed for cutting so you may want to think about gearing it 2:1 and increase torque and resolution.?