What do you plan to cut on this?

1st impressions:
Gantry looks weak in Y & Z directions, you're relying on Y-rail & supports for rigidity with no diagonal bracing. 10mm side panels might not be rigid enough. Also hard to tell what Y sbr20 are attached to so resistance to vertical deflection in Z may be an issue.

Probably want 1610 screws on X & Y.