I can generate a toolpath, and as far as I can tell I have done so (created the .nc file form the .dxf).

Indeed, a program called CutViewer Mill appears to show the cuts in a sensible fasion.

Still unsure as to how to organise the z-axis plunge, since I think this is still missing from my design...

Perhaps i'll look into LazyCam or something else as I dont think Artios is an ideal program to use for designing.