Wouldn't have the bottom rail that way around personally due to cutting forces and way it doesn't support the front plate. Personally would have top & bottom.
Also I wouldn't make the Y axis wrap around the gantry like that. It doesn't add hardly any strength makes the whole Y axis heavier than needed lowering accelration and increasing inertia plus it makes building harder because unless the Ends are perfectly 90deg they twist and bind the bearings.

Also rather than having the gantry cross beam central to the bearing try offsetting it back a little to allow for Z axis and spindle balancing the centre of Gravity better.