DIY vacuum might be a bit more tricky, but I don't see how an expensive high quality vacuum system overcomes the biggest resetting issue which you have already mentioned in passing. What's all this nonsense about clocking each piece? Clamp down the spoil board, then use the router to drill holes for locating pins. You'll surely do something like this with a vacuum hold-down? After that, it's difficult to believe that toggle clamps are much slower than vacuum. The difference in cost could go to some really nice cutters, which might even reduce the cutting time by more than the difference in clamping time!