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It is your design, your money.

5m/min with 10mm pitch is 500rpm.

It is better to choose 2020 screw...

I do not understand why you need "rapid" speed. It is hobby machine, and it is CNC....

Drive should be defined based of the performance.

Gantry mass play role, however if acceleration is 1200steps/second assuming 200 steps/rev this means 6 rev/s, acceleration of the gantry will be...

Very rigid CNC frame

x 400
y 150
z 200


no backlash

unfortunately too small for my needs.