Here's where I throw a spanner in the works.

This is from my own way of working I think you are going way overboard with the construction of the Z axis adding more and more to it.

I made a Z axis 510mm high x 220mm wide using 12mm backing plate with cut outs to ease the weight on the Y axis with 20mm Hywin rails direct on the plate no packers and carriages direct on the spindle plate, I made a rotating ball nut and fixed 1605 screw which helps to have the very minimum of overhang and adds to the strength of the design.
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It carries a German 2.2kw water cooled spindle, (I know not as heavy as yours) I do not get any drop of the Z when powered off weather this is down to the 2 to 1 reduction to the nut I am not sure but it works very well, it has cut wood, plastics, aluminium, steel plate and stone with no problems whatsoever.

Recently I setup a 4th axis to cut 2 1/2D designs around the edges of 150mm disks again works really well.
I am currently designing another machine with extended Y axis to be able to have a 4th axis running down the length of the X axis, and be able to cut around 300mm dia disks and have no problem using the same kind of design in fact I am going to use a rotating ball nut on the X & Y axis as well it is more compact and so smooth compared to turning screws.
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Phill