New Mill losing steps

[JAZZCNC]

Are you sure it's loosing steps or just not moving the correct amount.? Those numbers for X & Y suggest 2.5mm pitch running 2000 micro steps which would work out 800 Steps per and your not set to that amount so would be some error.?
Similair with Z axis and working on same pitch but with 1000 micro step = 400 steps per again your not quite there.!

Need lot more info to help correctly with setup and what can achieve.

Voltage the drivers are using. (also make and model of drives)
Micro stepping set on drives.
Ballscrew or Lead screw and the pitch. Ie distance traveled for one Revolution.
Units set in Mach Ie: MM or inch

What size motors and frame size Ie Nema 23 or 34.? They look like 34's.!

I see a Laptop in back ground are you using this to run machine via parallel port.?

Give this info and we can help better thou you should be getting much more than you are now without loosing steps.